Inflammation is a leading cause of many chronic diseases.
In Ayuverda and traditional Chinese medicine, curcumin has been used to treat inflammatory diseases for centuries.
Extensive research has shown that curcumin possesses therapeutic potential against proinflammatory diseases such as cancer, cardiovascular, pulmonary, metabolic, autoimmune and neurogenerativc diseases, and gastrointestinal disorders.
Inflammatory Mechanism of Curcumin
Curcumin is able to regulate various molecular targets that are linked to inflammation. They include transcription factors, cytokines, protein kinases, adhesion molecules, redox status and enzymes.
As curcumin suppresses inflammation, it has potential for prevention and treatment of the following pro-inflammatory diseases:
Clinical trials, animal studies and cell culture have demonstrated the anti-cancer potential of curcumin in various types of cancers, especially:
- Multiple myeloma
- Head and neck squamous cell carcinoma
- Vascular dysfunction
- Cardiac hypertrophy
- Myocardial ischemia
- Heart failure
Pulmonary (Lung) Diseases
- Allergic asthma
- Acute respiratory distress syndrome
- Chronic obstructive pulmonary disease
- Lung fibrosis
Metabolic syndrome refers to a cluster of risk factors for cardiovascular disease and/or type 2 diabetes. These factors include large waistline, high blood pressure, high triglyceride levels, low high density lipoprotein (HDL) and high blood sugar.
Animal studies showed that curcumin can lower LDL cholesterol, triglycerides and blood sugar levels, and inhibit LDL oxidation.
Human studies showed that curcumin supplementation lowered LDL cholesterol and triglycerides, raised HDL cholesterol, improved blood markers of inflammation in participants with metabolic syndrome.
- Rheumatoid athritis
- Oral lichen planus
- Sjögren’s syndrome
- Systemic lupus erythematosus
- Parkinson disease
- Alzheimer’s disease
- Multiple sclerosis
- Inflammatory bowel disease
- Irritable bowel syndrome